Phong Truong

 

Mentor: Dr. Todd Golde

College of Medicine

"I became interested in research because I loved the idea of achieving the ultimate challenge, that is, moving translational research from bench side to bed side. With this in mind, I had the desire to join Dr. Golde's lab. Although, I was just an undergraduate among many accomplished scientists, I felt that even the most basic tasks I performed could potentially help millions of lives that suffer from neurodegenerative disorders. Thus, it was this reason and my love for challenges that motivated me to become involved in research."

Major

Microbiology and Cell Science

Minor

N/A

Research Interests

  • Neurodegenerative Diseases
  • Cancer

Academic Awards

  • Summer Research Internship at Johns Hopkins University (2017)
  • Arthur and Anna Sahakian Scholarship (2017-2018)
  • Emerging Scholars Program (2016-2017)

Organizations

N/A

Volunteer

  • Hospice Care
  • Wilmot Gardens

Hobbies and Interests

  • Fly Fishing/Fishing
  • Sports
  • Working Out
  • Trying New Food

Research Description

Targeting the Stress Pathway with AAV Delivered Immunotherapy as a Novel Strategy against Alzheimer's Disease
Currently, there is no cure for Alzheimer's Disease (AD). Our goal is to use novel immunotherapeutic strategies to target the body's stress pathway to hopefully create future treatment for AD. One of the hallmarks of AD is hyperphosphorylated tau protein which aggregate to form neurofibrillary tangles (NFTs). These NFTs have been shown to have toxic effects and may be the cause of AD. Our main project is to manipulate the immune system to target pathological tau to the proteasome for degradation. We can do this by using an adeno-associated virus (AAV) to deliver an engineered gene to manipulate gene expression and therefore, altering pathological tau levels.