Presenters: Case, S. J., Copley, C. M., Davidson, C. G., Gain, I. C. M., Grant, K. A., Myers, S. S., Parker, G. A., Patel, M. D., Pettit, P. A., Portuondo, M. V., Shi, M. G., Starr, A. P., Towbin, N. L. M., Vick, J. A., Xia, A. L., Aurelia, C., Annarumma, S., Winesett, S. P., Borum, P. R.
Faculty Mentor: S. Parrish Winesett and Peggy R. Borum
College: College of Agricultural and Life Sciences
More than a third of the 65 million people with epilepsy do not respond adequately to medical treatments. We have known for centuries that seizures improve with fasting. A century ago, diets low in carbohydrates were shown to increase circulating ketones (nutritional ketosis) and to reduce seizures.
A precision medicine approach to dietary treatment of refractory epilepsy requires precise quantitation of intake at the level of nutrient composition of macronutrients. The nutrition facts label provides macronutrient data for specific lots of specific brands of food products available to patients. However, these data change as lots change. Since these data are not available as a database, we are creating an updated Nutrition Facts Database (NFD) that will be used to create recipes to administer the diet prescription of patients receiving Precision Ketogenic Therapy (PKT).
Pictures of all aspects of the food label are taken and documented. Data are entered into the NFD and audited. Effort is made to include all the favorite foods of patients to enhance compliance.
NFD will be used in the future to create a Foodomics Database to calculate patient intake of individual amino acids and fatty acids.