Analyzing the Correlation Between Prenatal THC Use and Issues in Cognitive Development After Birth

Michelle Hsia

Authors:  Michelle Hsia, Kyle Fontaine, Angie Miller, Vishal Ila, Michael Paiva, Marieta Heaton

Faculty Mentor: Marieta Heaton

College:  College of Medicine

Abstract

As popular use of marijuana increases in the general public, it has become more and more important to look at potentially detrimental effects of its use during pregnancy. Little research has been conducted in this area thus far, and the information gathered from this research could be critical in terms of public health prevention in the future. In this study, neonatal male and female mice will receive subcutaneous injections of THC from P4-P9. This period is equivalent to the human third-trimester, during which the developing cortex and hippocampus are highly vulnerable. Assessing both males and females is important, since gender-linked differences in developmental sensitivity have previously been found during the use of ethanol, and this is a trend we expect to see again. Following P9, I will conduct behavioral rotor rod and water maze testing on both mice who have been injected with THC and mice who have not. I will be blinded during these procedures as to not provide bias. After their conclusion, I will use histology to identify whether or not THC injection has had a detrimental effect on the neurological systems of these mice at the cellular level.

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Valerie Prytkova
Valerie Prytkova (@guest_788)
1 year ago

Michelle!!!

The most beautiful and well-spoken individual… I LOVE how applicable, important, and understandable your research is! You are a ROCKSTAR!!!!

Val.

Michelle Hsia
Michelle Hsia (@guest_964)
Reply to  Valerie Prytkova
1 year ago

Valerie!

Thank you for your kind words, and I am so excited to see your work soon!

Michelle Hsia
Michelle Hsia (@guest_1160)
1 year ago

https://ufl.zoom.us/j/2028662681

Here is a link if anyone had questions and was experiencing issues commenting!

Ashley Castano
Ashley Castano (@guest_1982)
1 year ago

Michelle,

First of all, I am so proud of you! You conducted thought-provoking and informative research with Kyle, Angie, Vishal, Michael, and Marieta. This was an interesting topic that helped inform me of the effects due to cannabis on the CNS during developmental periods. Keep pursuing research and medicine! You’re going to make an incredible physician one day!

Best,
Ashley Castano

Michelle Hsia
Michelle Hsia (@guest_2842)
Reply to  Ashley Castano
1 year ago

Hi Ashley,

Thank you so much for your kind words! I am so happy to be able to provide any information that might contribute to the dissemination of important scientific inquiry. I know that you are also doing incredible work in research, and I cannot wait to see your finished product as well.

Sophia Paulitz
Sophia Paulitz (@guest_2226)
1 year ago

Michelle,

This is an interesting and super relevant topic! Would you consider investigating this topic further and, perhaps, investigating the impact of CBD use as well? Great job!

Michelle Hsia
Michelle Hsia (@guest_2722)
Reply to  Sophia Paulitz
1 year ago

Hi Sophia,

This is a fantastic question! CBD use definitely has somewhat less of a stigma surrounding medicinal use. I still think that certain prejudices exist but much less so considering that it does not have the same psychoactive effect that THC does. I would personally love to dive into this research more and answer some questions about whether or not it does have detrimental effects if used prenatally. Thank you so much for your inquiry!

Dennis Le
Dennis Le (@guest_3508)
1 year ago

Love the idea behind the project! Quick question what was the mouse line?

Michelle Hsia
Michelle Hsia (@guest_3680)
Reply to  Dennis Le
1 year ago

Hi Dennis,

The mice used were heterozygous bax +/- breeding pairs on a C57BL/6 background, purchased from the Jackson Laboratory!

Mary Jo Koroly
Mary Jo Koroly (@guest_4122)
1 year ago

Excellent presentation and work on a very important topic, Michelle!

Jackson Dillard
Jackson Dillard (@guest_4434)
1 year ago

Excellent job, Michelle!

Bryn Tolchinsky
Bryn Tolchinsky (@guest_5338)
1 year ago

Great work Michelle. This is a very important study as marijuana becomes more widespread in recreational and medical uses. You are awesome!

Dylan Burgin
Dylan Burgin (@guest_5498)
1 year ago

Terrific project Michelle!