Authors: Christopher Najjoum
Faculty Mentor: Malisa Sarntinoranont
College: Herbert Wertheim College of Engineering
Brain parenchyma does not possess lymphatic vessels, however, the brain is one of the most metabolically active organs in the human body. Instead of a lymphatic vessel network, cerebral spinal fluid (CSF) is involved in transporting molecules throughout the brain. In the fields of Alzheimer’s disease and sleep, studies show interest in small interstitial fluid spaces around blood vessels called perivascular space (PVS) that contributes to waste clearance and drug delivery. The goal of this research was to visualize the PVS flow patterns through large interstitial fluid spaces that are connected to the PVS called ventricles. Previous work observed the PVS through magnetic resonance imaging (MRI) by injecting tracer into the ventricles of five different rat brains. Using the MRIs that were taken from earlier research, the goal was accomplished by segmenting/removing the ventricles from the PVS to create anatomical maps which were input into computational fluid dynamics models to predict physiological flow patterns.