Annette de Kloet, PhD

Mentor
Annette de Kloet, PhD
Project Title
The neural regulation of cardiometabolic function.
College
College of Medicine
Time Commitment
11-15 hours/week ,16-20 hours/week ,20+ hours
Method
Unpaid with future paid opportunities
Location of Research
On-Campus
Possible Co-Authorship
Yes

Project Description

Our laboratory uses an integrative approach in order to evaluate neural circuits involved in blood pressure and metabolic regulation.  A particular interest of the group is in determining the mechanism(s) by which metabolic and psychological stressors disrupt these neural circuits and contribute to the co-morbidity among metabolic, cardiovascular and stress-related diseases. The mutli-level approach used by the laboratory spans the use of several molecular, genetic, physiological and behavioral techniques that are performed in laboratory mice.  Some examples of the approaches used are: telemetry, which is used to assess cardiovascular parameters; optogenetics, in vivo calcium imaging, neuronal tract tracing, mRNA in situ hybridization, and immunohistochemistry, which are used to characterize the structure and function of specific sets of neurons; and genetic recombination techniques, which allow for the manipulation of gene expression in specific cellular phenotypes.  Multiple projects utilizing different combinations of these techniques are ongoing

Additional Requirements
None

Contact Information

Email Address
adekloet@ufl.edu
Phone Number
0