This project is a systematic review of multiple recent meta-analysis and associated sources from high impact medical journals. The purpose of the study is to assess the methodological quality of these studies with the intent to unmask the frequency and nature of successes and failures in study designs of a current trend in medical publication. Meta-analysis is a frequently employed tool for evidence-based medicine in spite of its numerous limitations. An observational review of published meta-analyses shows that they seldom result in a conclusion that refutes that of the best study included in the analysis. This study will investigate the frequency in which meta-analysis substantially alters or leads to a change in paradigm. This study will systematically evaluate the frequency for which meta-analysis make a significant contribution to the medical literature. We will review consecutive meta-analyses published in high-impact journals using a predefined screening tool. The student who participates in this project will perform an extensive literature review of significant clinical questions and will improve skills in evaluation of medical literature. The student will be expected to work with the PI to prepare a manuscript for publication.
Additional requirements: Background in Statistics is preferred.
Email: Michael.Bubb@medicine.ufl.edu, Reuben.Judd@medicine.ufl.edu, firstname.lastname@example.org, email@example.com