Dr. Bubb’s laboratory studies the regulation of actin polymerization in cell motility. We investigate the cell biology and biochemistry of actin-binding proteins specifically as they pertain to such topics as apoptosis, angiogenesis, immunology and cancer biology. We also study pharmacologic agents that affect actin polymerization. We use a variety of biophysical techniques to answer specific questions regarding mechanisms controlling cell motility, including time-dependent fluorescence spectroscopy and analytical ultracentrifugation. Many of the projects in the laboratory are translational, meaning that they will hopefully lead to clinical therapies for such diseases as rheumatoid arthritis and osteoarthritis. Dr. Bubb also studies medical reasoning and has ongoing projects related to the field of evidence-based medicine.