Nicole Chambers, PhD

Nicole Chambers, PhD
Project Title
Movement Effects of an Early Stage Mouse Model of Parkinson’s Disease
Herbert Wertheim College of Engineering
Time Commitment
11-15 hours/week ,16-20 hours/week ,20+ hours ,6-10 hours/week
Research Credit Unpaid
Location of Research
Possible Co-Authorship

Project Description

This opportunity is most suitable for those majoring in neuroscience, as this project centers around a mouse model of Parkinson’s disease. Parkinson’s disease is a movement disorder that is often associated with loss of dopamine neurons in the substantia nigra. Much of the existing research on Parkinson’s disease in rodents uses late-stage models with profound dopamine cell loss (>90% loss). In our lab we employ an early mouse model of Parkinson’s disease to investigate how changes in dopamine neurotransmission affect movement. This research project involves training mice on a floating ball treadmill apparatus, with the potential to also learn data analysis, sectioning mouse brains for immunohistochemistry, and observation of surgery and calcium imaging. Hands-on training will be provided. 

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