Closed head traumatic brain injury has been a major component of injury in battle field with lingering quality of life eroding disabilities such as spasticity, gait, balance, anxiety and cognitive disorders that produce a substantial health care responsibility. There are also rapidly growing concerns that TBI is a risk factor for lingering inflammation that can significantly increase the risk of progressive neurodegenerative disorders in the future. Accordingly, there is an urgent need to increase our understanding of injury-induced long-term disability mechanisms, and to test the safety and efficacy of therapeutic measures that target these mechanisms utilizing approaches that have excellent potential for rapid translation. The proposed studies focus on TBI-induced microbleeds mediated neural, vascular, and inflammatory injury and their treatment. Translation of these findings may provide safe and effective intervention strategies that can significantly benefit the veterans’ and civilian with TBI.
Phone: (352) 376-1611 x105996