In the field of neural interfaces, chronically implanted neural interfaces in the CNS lead to an encapsulating glial scar. While other non-mammalian species have shown remarkable ability to fully regenerate tissue, such as the axolotl, the African Spiny Mouse (ASM) is the only known mammal able to fully regenerate injured tissues with minimal scarring. The unique regenerative abilities of this species make it a prime candidate for investigating the foreign body response (FBR) to implanted devices, which has traditionally been a highly variable and complex system to understand. Alexis’ project will provide a baseline examination of the cellular morphology of the African Spiny mouse brain in the context of implantable neural interfaces and is intended as the first step in investigating how the regenerative abilities of the African Spiny mouse could impact current understanding of the FBR and neuroregeneration.