Student NameBasil Hashimi
Faculty Mentor NameHabibeh Khoshbouei
CollegeCollege of Medicine
Research InterestsNeurodegenerative diseases, Immunology, Monocytes and macrophages, Dopamine transporter, Myeloid-derived suppressor cells
Academic AwardsUF President's Honor Roll, UF Dean's List
OrganizationsAlpha Epsilon Delta, UF Global Medical Training, UF Neuroscience Club, Health Educated Asian Leaders
Hobbies and InterestsListening to music, Watching and playing sports, Attending concerts, Traveling

Research Project

Characterization of CNS infiltrating myeloid-derived suppressor cells in Parkinson's Disease

Parkinson’s disease (PD) is a disease characterized by dopaminergic neurodegeneration. While the process has been studied for decades, mechanistic insight into the cause of PD has remained elusive. My project is focused on studying the mechanistic relationship between the peripheral immune system and central nervous system in PD pathology. For the past year, we have successfully established a flow cytometry protocol to detect DAT, TH and CD14 expression in PD monocytes relative to healthy controls as a potential biomarker for PD. We have made the surprising discovery of increased DAT/TH expressing monocytes in PD patients versus healthy controls. Our data support the hypothesis that the CD14+ population is composed of multiple subsets of monocyte cells, including myeloid-derived suppressor cells (MDSCs) capable of altering the peripheral, and potentially the CNS, immune landscape. In order to further explore the nature of altered monocyte populations in PD patients, my project will be focused on conducting an extensive characterization of the altered PD monocyte population by investigating the presence of MDSCs in peripheral circulation. Using flow cytometry, I will study potential biomarkers in PD monocytes to identify specific subsets with altered trafficking and cytokine secretion profiles relevant to PD pathology and neurodegeneration.