Chandler Lentovich

Student NameChandler Lentovich
Faculty Mentor NameJenny Wilkerson, PhD.
CollegeCollege of Pharmacy
MajorHealth Science
Research InterestsBehavioral Pharmacology, Pharmacodynamics, Pharmacokinetics, Drug Development, Addiction, Pain
Academic AwardsUF Dean’s List, Fall 2018
UF Dean’s List, Spring 2019
UF Dean’s List, Fall 2019
UF Dean’s List, Spring 2020
UF College of Pharmacy University Scholars Program, 2020
Organizations Alpha Epsilon Delta, UF Honors College, Theatre Strike Force
Hobbies and InterestsTeaching Assistant, Improvisational Comedy

Research Project

The Effects of Terpenes and Minor Cannabinoids on Immune Response to Pain in a Mouse Model

Paclitaxel, a chemotherapeutic agent, is known to cause chronic peripheral neuropathy. There are a myriad of compounds found in marijuana that hold promise as novel therapeutic agents for chronic pain. These compounds may have cannabinoid receptor agonist properties. Agonistic effects at cannabinoid receptors CB1 (primarily found on neurons) and CB2 (primarily found on immune cells) could affect neuronal pain signaling and inflammation within the body. It is also possible that activation of cannabinoid receptors, as well as other key receptors, may cause modulation of proinflammatory markers. In this project, immunohistochemistry methods will be used to analyze the effects of the terpenes γ-terpinene, α-terpineol, β-caryophyllene on pro- and anti-inflammatory immune responses in a mouse paclitaxel-induced peripheral neuropathy model.