Paclitaxel, a chemotherapeutic agent, is known to cause chronic peripheral neuropathy. There are a myriad of compounds found in marijuana that hold promise as novel therapeutic agents for chronic pain. These compounds may have cannabinoid receptor agonist properties. Agonistic effects at cannabinoid receptors CB1 (primarily found on neurons) and CB2 (primarily found on immune cells) could affect neuronal pain signaling and inflammation within the body. It is also possible that activation of cannabinoid receptors, as well as other key receptors, may cause modulation of proinflammatory markers. In this project, immunohistochemistry methods will be used to analyze the effects of the terpenes γ-terpinene, α-terpineol, β-caryophyllene on pro- and anti-inflammatory immune responses in a mouse paclitaxel-induced peripheral neuropathy model.