Isadora Braga

Isadora Braga

Mentor

Dr. Guillaume de Lartigue

College

College of Pharmacy

Major

Biomedical Engineering

Minor

N/A

Organizations

Disability Ambassadors

Academic Awards

University Scholars Program Fellowship

Volunteering

N/A

Research Interests

Neuroscience and pharmacodynamics

Hobbies and Interests

Some of my hobbies are exercising, dancing, playing tennis, and enjoying a sunny day at the beach

Research Project

Asymmetrical Recruitment of Vagal Motor Neurons by Vagal Sensory Neurons that innervate the duodenum

The vagus nerve contains both afferent and efferent fibers to bidirectionally communicate information between the gastrointestinal (GI) tract and the central nervous system (CNS). It has emerged as a potential therapeutic target to treat obesity and other intestinal diseases. The neuropeptide cocaine-and amphetamine regulated-transcript (CART) is a subpopulation of vagal neurons that innervate the whole length of the gut and convey information of meal-borne signals to the brain. Targeting CART expressing neurons in transgenic mice with viral tools is a great approach to explore the neural circuits that are recruited by the vagus nerve in response to meal-borne signals.

The project’s goal is to investigate the central pathways and functional outcomes in response to tissue specific stimulation at the level of the duodenum.