Examining the role of the CXCR2 receptor in relation to Interleukin-8 and CXCL1 chemokines on inducing cachexia in pancreatic cancer patients. Investigates the mechanisms by which muscle wasting occurs in cachectic patients by genetically modifying the presence of absence of the CXCR2 receptor. This research aims to determine the vital roles of inducing cachexia in pancreatic cancer patients in order to manipulate them to combat the significant body and muscle mass atrophy.