Paxton Guerin

Paxton Guerin

Mentor

Dr. Josephine Allen

College

Herbert Wertheim College of Engineering

Major

Biomedical Engineering

Minor

N/A

Organizations

Society for Biomaterials, Gator Pals & Pi Beta Phi

Academic Awards

Dean's List and President's Honor Role

Volunteering

UF Health & Sidnie Lanier Center

Research Interests

Tissue engineering & regenerative medicine

Hobbies and Interests

I enjoy biomaterials and cell culture within my research, and in my free time I love going to the gym, playing sports, and spending time with my family, friends and dog!

Research Project

The Effect of Physiological Ions on Nucleic Acid-Collagen Complexes (NACCs) Stabilization

DNA and collagen are essential biomacromolecules in the body and in biomedicine. These molecules have physiological applications from ECM structure to regulating protein synthesis. Upon mixing the two molecules, they rapidly and spontaneously self-assemble into Nucleic Acid-Collagen Complexes (NACC). NACCs are physiologically relevant as an ECM component, and they have potential gene delivery applications. Additionally, they are relevant in tissue engineering and regenerative medicine as multimodal and bioactive scaffold material. It is apparent that electrostatic interactions between collagen and DNA molecules play a large role in NACC assembly and stability. We hypothesize that altering ion type and concentration when forming NACCs will impact their formation and stability.