Rohan Master

Rohan Master


Dr. Weizhou Zhang


College of Medicine


Preprofessional Biology




American Physician Scientists Association

Academic Awards

UF President's Honor Roll and UF Dean's List


UF Shands and North Florida Integrative Medicine

Research Interests

Cancer Biology, Cancer Immunotherapy, Immunology

Hobbies and Interests

Chess, movies, music, podcasts

Research Project

Developing a PROTAC-based NR4A1 Degrader for Cancer Therapy

Recent studies have highlighted the role of transcription factor nuclear receptor subfamily 4 group A member 1 (NR4A1) in melanoma for cancer survival, invasion, and metastasis. High expression of NR4A1 has also been implicated in tumor-infiltrating immune cells including TI-Treg cells and exhausted CD8+ T cells. My research focuses on developing an NR4A1 degrader using a proteolysis targeting chimera (PROTAC) drug design. The PROTAC can bind to NR4A1 and an E3 ligase to ubiquitinate NR4A1 and degrade it via the ubiquitin-proteasome pathway. By targeting NR4A1, we hope to achieve reduced cancer cell survival, while simultaneously improving the host’s immune response to cancer by reducing the suppressive function of TI-Tregs and re-activating the effector function of exhausted CD8+ T cells.