The current study is designed to investigate the relationship of a metabolite associated with neuronal integrity, NAA, to functional activity differences in response to tVNS in key brain networks known to decline with AD progression. Though it is likely that tVNS may affect the function of brain networks important in MCI, it is unknown to what extent brain deterioration may moderate/mediate the ability of tVNS to affect a useful change. Thus, in this study, we will determine to what extent neuronal integrity modifies the brain’s response to tVNS.
