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Srikar Savaram

Srikar Savaram

Mentor

Dr. Khoshbouei

College

College of Medicine

Major

Biochemistry and Behavioral Neuroscience

Minor

Health Disparities in Society

Organizations

CLAS Ambassador, CLAS Student Council, Asian American Student Association (AASU), Phi Delta Epsilon, General Intelligences Core team Leader, and UF Club Rowing

Academic Awards

N/A

Volunteering

RAHMA Mercy Clinic, Chemistry Club's Outreach Program, GNV Mentor, and ElderCare,

Research Interests

Dopamine Transporters biological responses,, Microglia response rate towards stroke, and Parkinson's disease

Hobbies and Interests

Working out, binging TV shows, sketching, and graphic design

Research Project

The role of Parkinson disease-linked gene VPS35 in dopamine transporters trafficking and dopamine neurotransmission

Parkinson’s disease is an age-related nervous system disorder that affects movement. It is characterized by a loss of dopaminergic neurons and was considered an environmental disease. However, 20 genes are linked to about 15% of Parkinson’s disease cases. The gene this project is focused on is the VPS35 D620N gene due to it being an autosomal dominant late-onset of Parkinson’s disease. The specific area to look at is the effects on dopamine with the gene of VPS35. There is evidence of VPS35 and Dopamine transporters (DAT) have interactions within the mouse striatum. The goal is to look at whether the VPS35 D260N has a relation to the loss of function within DAT recycling. This would lead to effects within the dopamine neurotransmission and age-dependent neurodegeneration. 

  • Dr. Khoshbouei
  • Biochemistry and Behavioral Neuroscience
  • Health Disparities in Society
  • Dopamine Transporters biological responses,, Microglia response rate towards stroke, and Parkinson's disease
  • N/A
  • CLAS Ambassador, CLAS Student Council, Asian American Student Association (AASU), Phi Delta Epsilon, General Intelligences Core team Leader, and UF Club Rowing
  • RAHMA Mercy Clinic, Chemistry Club's Outreach Program, GNV Mentor, and ElderCare,
  • Working out, binging TV shows, sketching, and graphic design
  • The role of Parkinson disease-linked gene VPS35 in dopamine transporters trafficking and dopamine neurotransmission

  • Parkinson's disease is an age-related nervous system disorder that affects movement. It is characterized by a loss of dopaminergic neurons and was considered an environmental disease. However, 20 genes are linked to about 15% of Parkinson's disease cases. The gene this project is focused on is the VPS35 D620N gene due to it being an autosomal dominant late-onset of Parkinson's disease. The specific area to look at is the effects on dopamine with the gene of VPS35. There is evidence of VPS35 and Dopamine transporters (DAT) have interactions within the mouse striatum. The goal is to look at whether the VPS35 D260N has a relation to the loss of function within DAT recycling. This would lead to effects within the dopamine neurotransmission and age-dependent neurodegeneration.