Tomas Cort

Tomas Cort

Mentor

Dr. Terence Ryan

College

College of Health and Human Performance

Major

Applied Physiology and Kinesiology

Minor

N/A

Organizations

N/A

Academic Awards

University Scholars Program 2021, President's List

Volunteering

Equal Access Clinic, Baby Gator Child Development and Research Center

Research Interests

Molecular Metabolism/ Mitochondrial Bioenergetics

Hobbies and Interests

Traveling

Research Project

Impact of Anastomosis in Chronic Kidney Disease: Developing a Validation Mouse Model of Arteriovenous Fistula

Currently, in the United States, there are approximately 425,000 patients receiving hemodialysis (HD) and it is estimated that 30-60% of this population have some element of hand dysfunction after hemoaccess surgery. The spectrum of hand disability that HD patients present with includes subtle fine neuromotor discoordination, paresthesia, pain, paraparesis and digital gangrene. The underlying pathophysiologic mechanisms responsible for this problem are poorly understood. More than 80% of patients have significant perturbations in hemodynamic variables such as wrist and digit pressures; however, these differences poorly correlate with changes in hand function. This heterogeneity in the clinical phenotype suggests that factors other than hand perfusion regulate development of hand dysfunction after arteriovenous fistula surgery.

The renal dysfunction milieu causes a variety of physiologic derangements in HD patients including increased oxidative stress and chronic inflammation that have been implicated as major contributors to accelerated atherosclerosis and elevated mortality. The central hypothesis of the proposed study is that renal dysfunction alters baseline mitochondrial function in skeletal muscle and neuromuscular junction, but the magnitude of this change is insufficient to lead to the clinical phenotype (i.e. altered hand function). I will focus on determining if global and/or mitochondrial-targeted antioxidant therapies can improve neuromuscular function and reduce pathology following AVF placement in mice.

  • Dr. Terence Ryan
  • Applied Physiology and Kinesiology
  • N/A
  • Molecular Metabolism/ Mitochondrial Bioenergetics
  • University Scholars Program 2021, President's List
  • N/A
  • Equal Access Clinic, Baby Gator Child Development and Research Center
  • Traveling
  • Impact of Anastomosis in Chronic Kidney Disease: Developing a Validation Mouse Model of Arteriovenous Fistula
  • Currently, in the United States, there are approximately 425,000 patients receiving hemodialysis (HD) and it is estimated that 30-60% of this population have some element of hand dysfunction after hemoaccess surgery. The spectrum of hand disability that HD patients present with includes subtle fine neuromotor discoordination, paresthesia, pain, paraparesis and digital gangrene. The underlying pathophysiologic mechanisms responsible for this problem are poorly understood. More than 80% of patients have significant perturbations in hemodynamic variables such as wrist and digit pressures; however, these differences poorly correlate with changes in hand function. This heterogeneity in the clinical phenotype suggests that factors other than hand perfusion regulate development of hand dysfunction after arteriovenous fistula surgery.

    The renal dysfunction milieu causes a variety of physiologic derangements in HD patients including increased oxidative stress and chronic inflammation that have been implicated as major contributors to accelerated atherosclerosis and elevated mortality. The central hypothesis of the proposed study is that renal dysfunction alters baseline mitochondrial function in skeletal muscle and neuromuscular junction, but the magnitude of this change is insufficient to lead to the clinical phenotype (i.e. altered hand function). I will focus on determining if global and/or mitochondrial-targeted antioxidant therapies can improve neuromuscular function and reduce pathology following AVF placement in mice.