Sarcopenia is the process of gradual muscle loss which is associated with age. Currently, treatment for sarcopenia consists of resistance exercise, but potential pharmacological treatments are still being evaluated. The primary aim of this investigation is to characterize the effects of varying electrical stimulation regimes and pharmacological treatments on functional, contractile human muscle bundles. The study will utilize microfluidic tissue chips, which will serve as platforms to generate 3D differentiated human muscle bundles. Post-treatment analysis of muscle bundle contractility and gene expression will enable us to better understand muscle atrophy processes, and may provide insights into possible future treatments for sarcopenia.