Sofia Acevedo

Sofia Acevedo

The impact animal-based vs plant-based proteins have on inflammation makers among adults with chronic kidney disease: A systematic review/meta-analysis


Danielle Aycart, Sofia Acevedo, Dr. Jeanette Andrade


Dr. Jeanette Andrade


College of Agricultural and Life Sciences


Background: Plant based proteins reduce inflammation among adults with chronic kidney disease (CKD). <P> Objective: This systematic review/meta-analysis was conducted to evaluate the effect plant-based proteins compared to animal-based proteins have on inflammation markers (CRP, IL-6, TNF-α) among adults with CKD. <P> Methods: The Preferred Reporting Items for Systematic Review and Meta-analysis was conducted to identify articles through December 2020, utilizing six databases: Medline, Pubmed, Embase, Cochrane Library, Scielo, Clinical Trials.Gov.. Controlled trials that compared the effects of protein types and amounts were analyzed using the random-effects meta-analysis. Quality assessment and risk of bias of included articles was completed. <P> Results: A total of 16189 papers were reviewed, with 10 meeting the criteria. Inflammation analysis showed limited effects of animal-based and plant-based protein with CRP levels [SMD:0.26; 95% CI: -0.15, 0.66]. <P> Conclusions: Overall, limited effects were observed among protein types and inflammation markers. Future research needs to be conducted using consistent measurement techniques and intervention lengths.


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